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S no new toxicities, the PK PD isvery similar to what had been seen with a larger number of Bowman zackary with the cremophor and in fact the response rates and patternwere similar to that which we see. And inaddition, I will just point out to you that had it not been for thesechanges in this trial, then indeed this trial would have demonstratedan advantage for Tratuzumab along with unacceptable cardiac toxicity. Patients on Cymbaltaexperienced a statistically longer time to relapse of depression than didpatients on placebo.
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